PC-3
Source: Organ: prostate
Tumor Stage: grade IV
Disease: adenocarcinoma
Derived from metastatic site: bone
DNA Profile (STR): Amelogenin: X
CSF1PO: 11
D13S317: 11
D16S539: 11
D5S818: 13
D7S820: 8,11
THO1: 6,7
TPOX: 8,9
vWA: 17
Comments: The PC-3 was initiated from a bone metastasis of a grade IV prostatic adenocarcinoma from a 62-year-old male Caucasian.
The cells exhibit low acid phosphatase and testosterone-5-alpha reductase activities.
DU145
Source: Organ: prostate
Disease: carcinoma
Derived from metastatic site: brain
DNA Profile (STR): D7S820: 7, 10, 11
D13S317: 12, 13, 14
D5S818: 10, 13
vWA: 17, 18, 19
THO1: 7
CSF1PO: 10, 11
TPOX: 11
D16S539: 11, 13
Amelogenin: X, Y
PC3 細胞系: 是從人前列腺癌骨轉移腫瘤中分離出來的，分化程度低，為雄激素非依賴性前列腺癌細胞，不含有內源性的雄激素受體，具有中等強度的轉移潛能，被廣泛用于雄激素抵抗型的前列腺癌的研究。PC3 細胞高表達 E-cadherin，不表達 Vimentin
DU145 細胞: 是從前列腺癌腦轉移腫瘤中分離出來的，分化程度低，為雄激素非依賴的前列腺癌細胞，具有強大的轉移潛能，缺乏內源性的雄激素受體的表達［7］。DU145 細胞完全貼壁的時間通常在 24 h 以內。具有較強的侵襲和促血管新生能力，高表達 VEGF 和 EGFR。DU145 細胞高表達 Vimentin，不表達 E-cadher-in。
