| Comments |
mAb 5C6 was the product of a fusion between spleen cells from an AO rat, immunized four times with TPM, and fused with the Y3 rat myeloma line.
The antibody reacts with the mouse myelomonocytic adhesion promoting complement receptor (CR3, CD11b).
It inhibits myelomonocytic adhesion in vitro, and recruitment of inflammatory cells in vivo. |
| References |
Rosen H. Role of CR3 in induced myelomonocytic recruitment: insights from in vivo monoclonal antibody studies in the mouse. J. Leukocyte Biol. 48: 465-469, 1990. PubMed: 2230596
Hutchings P, et al. Transfer of diabetes in mice prevented by blockade of adhesion- promoting receptor on macrophages. Nature 348: 639-642, 1990. PubMed: 2250718
Rosen H, Gordon S. Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro and inflammatory cell recruitment in vivo. J. Exp. Med. 166: 1685-1701, 1987. PubMed: 2445894
Hay, R. J., Caputo, J. L., and Macy, M. L., Eds. (1992), ATCC Quality Control Methods for Cell Lines. 2nd edition, Published by ATCC.
Caputo, J. L., Biosafety procedures in cell culture. J. Tissue Culture Methods 11:223-227, 1988.
Fleming, D.O., Richardson, J. H., Tulis, J.J. and Vesley, D., (1995) Laboratory Safety: Principles and Practice. Second edition, ASM press, Washington, DC.
|
